منابع مشابه
Dmd053322 2018..2023
In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...
متن کاملSome Info on Info Theory
Understanding causal relationships, oreffective connectivity, between parts of the brain is ofutmost importance because a large part of the brain’sactivity is thought to be internally generated and,hence, quantifying stimulus response relationshipsalone does not fully describe brain dynamics. Pastefforts to determine effective connectivity mostly reliedon model based...
متن کاملDmd059675 2023..2032
Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer’s disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further understanding of the metabolism and disp...
متن کاملDev104240 2014..2023
Tissue homeostasis is maintained by adult stem cells, which selfrenewand give rise to differentiating cells. The generation of daughter cells with different fates is mediated by signalling molecules coming from an external niche or being asymmetrically dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate ...
متن کاملJanuary 2016.htm
The Department of Anesthesiology at the University of Toledo has been blessed to have had two pioneers in the specialty of anesthesia as faculty members. John (Tom) T. Martin, M.D. was the second Chairman of the Department and a world expert who literally wrote the book on Positioning in Anesthesia and Surgery and associated nerve injuries. He was a prolific writer authoring or co-authoring 48 ...
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ژورنال
عنوان ژورنال: HTM Journal of Heat Treatment and Materials
سال: 2023
ISSN: ['1867-2493', '2194-1831']
DOI: https://doi.org/10.1515/htm-2023-2005